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- _3 value "prohibitin regulates E2F function Rb repressed E2F-mediated transcriptional activation through recruitment of complexes such as HDAC and Brg-1/Brm Co-repressors such as NcoR mediate the above process Rb and Prohibitin respond to different signalling pathways - Adenovirus E1A and cyclin-dependent kinases effect Rb and not Probitin - Stimulation of B cells through IgM releases prohibitin-mediated repression of E2F Viral oncoprotien SV40T inactivates Rb SV40T blocks interaction of Prohibitn with co-repressors, Brg-1 and Brm in vivo." provenance.
- _3 wasQuotedFrom 12065415 provenance.