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- _5 value "ER expression alters the transcriptional regulation of PPARG - targeted gene expression and reduces both basal and stimulated PPARG-mediated reporter activity, suggesting a cross-talk between PPARG andERsignaling in breast cancer cells (89). Activation of PPARG by PGJ2 results in a significant inhibition of ErbB-2 and ErbB-3 tyrosine phosphorylation caused by neuregulin 1 (NRG1) and neuregulin 2 (NRG2) in MCF-7 cells (90)" provenance.
- _5 wasQuotedFrom 14587863 provenance.