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- _8 value "Finally, the pit-1 gene itself is regulated by an enhancer element located 10 kb upstream of the transcriptional start. This element contains several pit-1 DNA binding sites and retinoic acid response elements (RAREs). On one of these elements, pit-1 and RAR interact functionally to mediate a synergistic response to RA. Recent data from our laboratory suggests that RA induction of the pit-1 gene can be impaired by pit-1 gene mutations." provenance.
- _8 wasQuotedFrom 9554467 provenance.