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- _4 value "activation of the HIF-1 pathway leads to downregulation of the tricarboxylic acid cycle and oxidative phosphorylation. This is accomplished through the stimulation of pyruvate dehydrogenase kinase 1 expression that, by inhibiting pyruvate dehydrogenase, inhibits the conversion of pyruvate to acetyl-CoA[35,36]." provenance.
- _4 wasQuotedFrom 17885420 provenance.