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- _5 value "Transfection of U87MG and T691 cells with Gab1 and SHP-2 independently with NF-kB-luciferase reporter construct which showed a 9-fold increase in luciferase activity in both U87MG transfected cells and U87MG/T691 compared with the empty vector and cotransfection of Gab1 with SHP-2 resulted in additional upregulation of NF-kB activity. Furthermore, cotransfection with a construct expressing myristoylated Akt increased NF-kB activity in parental and T691 cells by 4 and 3-fold respectively over the empty vector but no change when expressed with mutant Akt. Stimulation with EGF resulted in the robust activation of NFkB and showed a binding complex,suggesting that p65/p50 were involved in EGFR-mediated signalling." provenance.
- _5 wasQuotedFrom 14701753 provenance.