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- _4 value "Overexpression of SHIP2 blocks hypertrophy in muscle [6,7]. Expression of a dominant-negative mutant form of SHIP2 (dnSHIP2), in which the phosphatase has been rendered inactive, enables Akt1 to remain active by blocking the dephosphorylation of PtdIns(3,4,5)P3 [37]. Expression of dnSHIP2 in myotubes causes hypertrophy, coincident with an increase in the levels of phosphorylated Akt1 [6]." provenance.
- _4 wasQuotedFrom 12928036 provenance.