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- _5 value "At least nine intracellular substrates of the insulin/IGF-I receptor kinases have been identified (Fig. 2). Other substrates include Gab-1, p60dok, Cbl, APS and isoforms of Shc10. The phosphorylated tyrosines in these substrates act as 'docking sites' for proteins that contain SH2 (Src-homology-2) domains. Many of these SH2 proteins are adaptor molecules, such as the p85 regulatory subunit of PI(3)K and Grb2, or CrkII, which activate small G proteins by binding to nucleotide exchange factors." provenance.
- _5 wasQuotedFrom 11742412 provenance.