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- _4 value "To further define the mechanism for inhibition of the cytokine promoters by twist, we tested whether twist could inhibit NF-B activity, using a luciferase reporter driven by four canonical B binding sites (4xB-luc). This reporter can be induced by p65 or treatment with TNF. In either case, activation of the reporter was strongly inhibited by twist-2, as well as twist-1 (Figure 6D). These findings suggested that twist inhibits NF-B-dependent transcriptional activation." provenance.
- _4 wasQuotedFrom 12553906 provenance.