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- _5 value "Nicotine has been also found to upregulate the vascular endothelial growth factor receptor (VEGFR) in gastric carcinoma cells by stimulating the expression of COX-2. This stimulation of COX-2 triggers tumor cell invasion and angiogenesis through activation of VEGFR-2, which subsequently modulates matrix metalloprotease activity (MMP2 and MMP9) and the expression of plasminogen activators [33]." provenance.
- _5 wasQuotedFrom 18262664 provenance.