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- _3 value "Therefore, we examined the expression of several genes important in lipid metabolism in ATMs from normal diet and high-fat diet mice. Apoe was downregulated in ATMs with high-fat diet. Expression of both adipocyte differentiation?related protein (Adfp) and peroxisome proliferator activation receptor-? (Pparg) were increased in high-fat diet ATMs (Fig. 4A). To determine the functional significance of these findings, we examined the lipid content of ATMs isolated from normal diet?and high-fat diet?fed animals by Nile Red staining. Both macrophage (CD11b+) and nonmacrophage (CD11b?) cells in SVF cultures had Nile Red?positive vesicles; however, ATMs had more pronounced lipid accumulation, especially in obese mice " provenance.
- _3 wasQuotedFrom 17192460 provenance.