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- _5 value "Mechanistic studies revealed that HER2 trans-activation by IL-1?? required a disintegrin and metalloprotease 17 (ADAM17)-dependent shedding of the ligand neuregulin-1 (NRG-1). In murine models of ALI, NRG-1-HER2 signaling was activated, and ADAM17 blockade resulted in decreased NRG-1 shedding, HER2 activation, and lung injury in vivo." provenance.
- _5 wasQuotedFrom 21247898 provenance.