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- _4 value "When PPARg expression was restored with retroviral gene transfer, however, they differentiated well, suggesting that C/EBPa plays an important role in adipogenesis primarily by inducing the expression of PPARg. Ectopic expression of PPARg circumvents the requirement for C/EBPa in adipogenesis, at least with respect to lipid accumulation and most gene expression. Interestingly, C/EBPa -/- adipocytes created by ectopic expression of PPARg are not insulin sensitive, a deficiency that could be restored by re-introducing C/EBPa." provenance.
- _4 wasQuotedFrom 15936931 provenance.