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- _5 value "Nevertheless, the restored ability of pVHL-positive transfectants to assemble extracellular fibronectin was mediated by b1 integrins, implying that pVHL controls ECM assembly, at least in part, through integrin signalling [46]. A recent development has demonstrated that an ubiquitin-like molecule, NEDD8, covalently modifies pVHL and that a neddylation- defective pVHL mutant, despite retaining its ability to degrade HIF, fails to promote the assembly of a fibronectin matrix [47]." provenance.
- _5 wasQuotedFrom 15350900 provenance.