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- _5 value "The basal turnover of Cdc25A operating in unperturbed S phase required Chk1-dependent phosphorylation of serines 123, 178, 278, and 292. IR-induced acceleration of Cdc25A proteolysis correlated with increased phosphate incorporation into these residues generated by a combined action of Chk1 and Chk2 kinases. Finally, phosphorylation of Chk1 by ATM was required to fully accelerate the IR-induced degradation of Cdc25A ... from full text, U2OS cells and ATM-dependent CHEK1 phosphorylation at S317 and S345" provenance.
- _5 wasQuotedFrom 12676583 provenance.