Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAmTa1yAGIQgEMwfdMK68GqQ3COA4aAqiKc21y0OD_6Sw#_3> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _3 value "Indeed, the proportion of cardiac output that goes to adipose tissue is decreased in obesity, and the obese do not show the post-prandial increase in blood flow which occurs in lean individuals (Karpe et al. 2002). Activation of a transcription factor, hypoxia inducible factor-1 (HIF-1), through the stimulation of the expression of the HIF-1a subunit - the molecular sensor of hypoxia (Semenza 2001, Wenger 2002, Hopfl et al. 2004) - may be the mechanism through which low oxygen tension links to inflammation (Trayhurn & Wood 2004). The target genes for HIF-1 include VEGF and leptin, and expression of both of these has been shown to be stimulated in 3T3-L1 adipocytes in response to hypoxia (Lolmede et al. 2003)." provenance.
- _3 wasQuotedFrom 16026420 provenance.