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- _5 value "transcription factor HiNF-P, which is required for E2F-independent activation of the histone H4 multigene family. HiNF-P interacts with conserved H4 cell cycle regulatory sequences in vivo. Antisense inhibition of HiNF-P reduces endogenous histone H4 gene expression. Furthermore, we find that HiNF-P utilizes NPAT/p220, a substrate of the cyclin E/cyclin-dependent kinase 2 (CDK2) kinase complex, as a key coactivator to enhance histone H4 gene transcription." provenance.
- _5 wasQuotedFrom 14585971 provenance.