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- _4 value "This decrease in cell survival required the DNA binding domain of TEL, suggesting that TEL repressed an anti-apoptotic gene. These observations prompted us to search for genes regulated by ETS family proteins that regulate apoptosis. The anti-apoptotic molecule Bcl-XL contains multiple ets-factor binding sites within its promoters, and TEL repressed a Bcl-XL promoter-linked reporter gene.Moreover, the enforced expression of TEL decreased the endogenous expression of both Bcl-XL mRNA and protein." provenance.
- _4 wasQuotedFrom 12960174 provenance.