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- _4 value "(from text) We confirmed this essential role for huntingtin on our arrays, detecting the general down-regulation of genes involved in growth, proliferation and cellular differentiation (Fig. 6). A subset of these transcripts appear to function specifically within the brain: Serpinf1, Emp3, Tcfap2c, Dlx3 and Elavl4. Many general growth-related or mitogenic mRNAs (Ghrh, Scgb3a1, Cdkn1c, Sp6, Gkn1, Igf2) also exhibited reduced expression. Conversely, Hdh null neurons consistently overexpressed Ccng2, a negative regulator of cell proliferation and cell cycle progression." provenance.
- _4 wasQuotedFrom 17189290 provenance.