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- _5 value "To better understand the mechanism(s) through which pRb positively affects myogenesis and to ascertain why the later steps of myogenesis are specifically altered in the absence of pRb, we have further characterized the differentiation defects that are seen in pRb-deficient muscle cells. We demonstrate that the failure to activate late muscle-gene expression in pRbdeficient myocytes is due to a requirement for both MyoD and pRb in the activation of MEF2 transactivation-domain (TAD) function." provenance.
- _5 wasQuotedFrom 10322110 provenance.