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- _4 value "In fact, our studies indicate that VEGF/neuropilin-1 autocrine signaling promotes the migration of breast carcinoma cells by increasing the expression of the chemokine receptor CXCR4 [19]. Our finding that VEGF regulates CXCR4 expression is relevant because stromal-derived factor-1, the ligand for this receptor, is present in tumor stroma and in tissues such as lymph and lung [36], which are the primary targets of invasive breast carcinoma cells, and CXCR4 inhibitors impair metastasis." provenance.
- _4 wasQuotedFrom 15018895 provenance.