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- _3 value "GraB is a serine protease, but similar to the caspases, it cleaves substrates at Asp residues, including several caspases and some caspase substrates. a nuclear pathway for apoptosis regulation may exist which centers on discrete nuclear organelles, called Pml oncogenic domains (PODs) or nuclear bodies (NBs).Targeted ablation of the pml gene in mice results in general resistance to apoptosis through unknown mechanisms. Several proteins that can promote apoptosis have been localized to PODs, including Daax, Zip kinase, and Par4, and defects in assembly of these nuclear structures are documented in cancers (Salomoni and Pandolfi, 2002)." provenance.
- _3 wasQuotedFrom 12559172 provenance.