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- _5 value "Recently, it has been shown that ?Np63a is also overexpressed in HNSCC cell lines (including JHU-012) and in these cells, it acts as a crucial survival factor by suppressing p73-dependent apoptosis.29,32?34 Knockdown of ?Np63 induces the proapoptotic bcl-2-family members Puma and Noxa, and both their induction and cell death are p53-independent, but require transactivating isoforms of p73. The inhibition of p73-dependent transcription by DNp63a involves both direct promoter binding and physical sequestration of p73 by protein?protein interaction.29,34?35" provenance.
- _5 wasQuotedFrom 18483491 provenance.