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- _2 value "Furthermore, integrin ?1?1-null mice have been shown to be deficient in tumour angiogenesis42. The reason for this is thought to be that the expression of matrix metalloproteinase (MMP)-9 is elevated in the absence of ?1?1, which normally suppresses MMP-9 expression.As a result, more angiostatin - a peptide that suppresses angiogenesis - is produced by MMP-9- catalysed proteolytic cleavage of plasminogen. So, the pathways through which these integrins affect angiogenesis might be different from those used by ?v?3,?v?5 and ?5?1." provenance.
- _2 wasQuotedFrom 12635171 provenance.