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- _6 value "dominant negative mutant of SHP-2 was found to inhibit the induction of tyrosine phosphorylation and DNA-binding activity of m-Stat5a, m-Stat5b, and the carboxyl-terminal deletion variant m-Stat5adelta749, as well as the transactivation potential of m-Stat5a and m-Stat5b. The kinase activity of Jak2 is also dependent on a functional SHP-2 phosphatase" provenance.
- _6 wasQuotedFrom 9544991 provenance.