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- _4 value "Cell-specific prostaglandin synthases convert PGH2 into a series of prostaglandins, including PGI2, PGF2alpha, PGD2 and PGE2 (Fig. 1). Fig. 1 Legend - Pathway of prostaglandin production. Arachidonic acid is liberated from membranes by phospholipase A2. The cyclooxygenase enzymes (COX-1 and COX-2) produce prostaglandin H2 (PGH2) from arachidonic acid. PGH2 is acted upon by prostaglandin synthases to produce PGI2, PGD2, PGE2 and PGF2alpha. PGD2 is metabolized to 15-deoxy-12,14-PGJ2 (15-d-PGJ2). " provenance.
- _4 wasQuotedFrom 11864843 provenance.