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- _7 value "I. Stat The family of Stat molecules has seven members of which Stat1, Stat3, Stat5a and -beta , and Stat6 have been shown to bind to the activated PDGF beta -receptor and to be phosphorylated after PDGF stimulation; binding also occurs to the alpha -receptor, albeit only weakly (347, 474, 482). After phosphorylation on tyrosine, Stats dimerize and translocate to the nucleus, where they act as transcription factors (reviewed in Ref. 92). Stat molecules are important for the transduction of signals downstream of cytokine receptors; however, their importance in PDGF signaling remains to be elucidated." provenance.
- _7 wasQuotedFrom 10508235 provenance.