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- _3 value "A smaller PGC-1 transcript had appeared 6 h after a single bout of exercise (Fig. 2). Accumulation of a smaller form of the PGC-1 mRNA in muscle 6 h after exercise was a consistent finding in muscles from six rats. Determination of the identity of the smaller inducible PGC-1 transcript To determine what component of the PGC-1 coding region is represented in the smaller mRNA, four partial overlapping PGC-1 cDNA probes were used (Fig. 2). Probe 1 corresponds to nucleotides 42-612, probe 2 to nucleotides 349-1056, probe 3 to nucleotides 1056- 1557, and probe 4 to nucleotides 1039-2382. All four probes identify the full-length PGC-1 mRNA (Fig. 2, top band). However, only probes 1, 2, and 4 bind to the shortened form of PGC-1. These data suggest that the smaller form of the PGC-1 mRNA is the result of a differential splicing event that results in the removal of internal exons, including the large exon 8. PGC-1 gene expression is increased after a bout of exercise As shown in the Western blot in Fig. 3, PGC-1 protein concentration was increased in triceps muscle 18 h after a single bout of exercise." provenance.
- _3 wasQuotedFrom 12468452 provenance.