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Nicotine has been shown to accelerate cell proliferation by increasing the levels of both growth factors (e.g. BDNF, VEGF, HGF, VEGF-C, TGF-b, PDGF and TGF-a) and growth factor receptors (e.g. VEGFR-2, PDGFR, HGFR and EGFR) [30,31].
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