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- _2 value "Pathologies (splenomegaly, lymphadenopathy associated with lymphocytic infiltration, autoimmunity) associated with the Fasl KO mice are nearly identical to those of the Casp8 (PMID 16157684) (Casp8 is downstream of Fasl in the extrinisc apoptotic cascade that regulates B- and T-cell turnover) KO mice and due to uncontrolled proliferation of lymphocytes directly, a direct result of decreased lymphocytic apoptosis. Pathologies are due to uncontrolled proliferation of B- and T-cells in the absence of apoptosis." provenance.
- _2 wasQuotedFrom 14764677 provenance.