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- _3 value "five proteins previously identified to be downstream of Akt at the time of maximal nicotinic Akt induction: a member of the forkhead transcription factor family (FKHR), GSK-3? and -3?, a ribosomal kinase (p70S6K), and a binding protein for eukaryotic translation initiation factor 4E (4EBP-1) (Figure 2b). We observed different patterns of phosphorylation induced by nicotine or NNK. Nicotine increased the phosphorylation of all downstream substrates, but phosphorylation of GSK-3? and FKHR was induced most. NNK increased phosphorylation of all downstream substrates except FKHR and had the greatest effects on phosphorylation of GSK-3? and p70S6K" provenance.
- _3 wasQuotedFrom 12511591 provenance.