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- _4 value "FROM TEXT and Figure 6: Hybridization to the U133A DNA microarray, Genes downregulated in NANOG cells compared with both 2-day-old EBs and wild-type ES cells. These genes may also be targets of NANOG, which has been suggested to be both a transcriptional activator and repressor. In addition, genes reported to be upregulated upon knock-down of Nanog in MESCs (Mitsui et al., 2003) are downregulated upon overexpression of NANOG in HESCs. These include parietal endoderm markers (like LAMB1, downregulated by 3.5-fold)" provenance.
- _4 wasQuotedFrom 16501172 provenance.