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- _5 value "The PI3K pathway is negatively regulated by PTEN (phosphatase and TENsin homolog), which converts PIP3 in PIP2, preventing PKB activation and Bad phosphorylation/sequestration. Thus PTEN is considered as a tumor suppressor gene. It has been shown that NS-398 was able to increase the level of PTEN in human gastric carcinoma cell line MKN45 [114]. " provenance.
- _5 wasQuotedFrom 20339581 provenance.