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- _5 value "To confirm that increased Akt phosphorylation at S473 and T308 was indicative of increased kinase activity, we measured the phosphorylation of an exogenous peptide substrate, glycogen synthase kinase-3?/? (GSK-3?/?), after nicotine or NNK administration (Figure 2a). Nicotine or NNK increased Akt kinase activity in a PI3K-dependent manner, since the PI3K inhibitor LY294002 (18) inhibited induction of Akt activity by nicotine or NNK." provenance.
- _5 wasQuotedFrom 12511591 provenance.