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- _5 value "VHL loss of function results in a marked increase in HIF-1 activity in non- hypoxic conditions because of impaired VHL-dependent ubiquitylation and proteasomal degradation of HIF-1a and HIF-2a. Although the O2-dependent regulation of transactivation function is still intact, FIH-1 might become limiting under conditions of HIF-1a and HIF-2a overexpression, leading to increased transcriptionally active HIF-1 under nonhypoxic conditions in VHL-null cells." provenance.
- _5 wasQuotedFrom 13130303 provenance.