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- _4 value "Protein I/II-mediated IL-6 and IL-8 secretion in human FLSs was inhibited by 90% by curcumin and sulphasalazine (which inhibit NFKB activation by blocking a signal leading to IKK activity), indicating that IL-6 and IL-8 activation is mediated through NFKB. Protein I/II-mediated IL-6 and IL-8 secretion by human Fibroblast-like synoviocytes was also inhibited 90% by peptide L-6-L (a selective inhibitor of NFKB)." provenance.
- _4 wasQuotedFrom 11580755 provenance.