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- _3 value "It remains to be determined what the role of Ser-62 phosphorylation is in promoter selection or whether the phosphorylation is the consequence of targeting MYC to specific DNA sequences. Furthermore MYC mutated at Thr-58 fails to activate the expression of BIM, a proapoptotic BH3-only BCL2 family member, resulting in reduced apoptosis and enhanced tumorigenesis (38). Although MYC stimulates apoptosis by regulating many different genes (39, 40), MYC-stimulated expression of BIM is particularly relevant for repression of tumor development (41). BIM functions as a tumor suppressor, at least in MYC-driven B cell leukemia. This is independent of the status of the p53 tumor suppressor pathway that is viewed as an important mediator of MYC-induced apoptosis (39, 40)." provenance.
- _3 wasQuotedFrom 16987807 provenance.