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- _4 value "An early confluent culture of C2C12 cells pretreated with 10 microg/ml of cycloheximide (CHX) for 30 minutes and then treated with 300ng/ml of BMP-2 (bone morphogenetic protein2) for 1 day induced the expression of Dlx5. Moreover when Dlx5 was over-expressed by transfecting C2C12 cells with the Dlx5 expression vector, Alp expression was stimulated even in the absence of BMP-2 treatment and that Dlx5 and the product of its target gene, Runx2, stimulated ALP promoter activity in an additive manner. However, because Dlx5 continued to stimulate ALP expression in Runx2(-/-) cells, the ALP stimulatory activity of Dlx5 is independent of Runx2. Thus it suggests that Alp is a downstream target of Dlx5 and that Dlx5 and Runx5 can both regulate its expression." provenance.
- _4 wasQuotedFrom 15383550 provenance.