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- _3 value "# Ariadne: On the basis of our current results and those of others (Legay et al., 1995 ; see also Fontaine and Changeux, 1989 ; Tsay and Schmidt, 1989 ; Piette et al., 1993 ), it appears that during synaptogenesis and maturation of the neuromuscular junction, the activity-linked regulation of the AChE gene involves transcriptional and posttranscriptional regulatory mechanisms and that, in mature muscle, regulation of this synaptic protein is achieved primarily via posttranscriptional events. [Regulation] The molecular mechanisms underlying the activity-linked plasticity of acetylcholinesterase (AChE) mRNA levels in mammalian skeletal muscle have yet to be established. Here, we demonstrate that denervation of adult muscle induces a dramatic (up to 90%) and rapid (within 24 h) decrease in the abundance of AChE mRNAs." provenance.
- _3 wasQuotedFrom 10820184 provenance.