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- _4 value "Inhalation exposure of the mice to environmentally-relevant fine particulate matter (aerodynamic diameter < 2.5 mum, PM(2.5)) induces endoplasmic reticulum (ER) stress and activation of unfolded protein response (UPR) in the lung and liver tissues as well as in the mouse macrophage cell line RAW264.7. Ambient PM(2.5) exposure activates double-strand RNA-activated protein kinase-like ER kinase (PERK), leading to phosphorylation of translation initiation factor eIF2alpha and induction of C/EBP homologous transcription factor CHOP/GADD153. " provenance.
- _4 wasQuotedFrom 20554909 provenance.