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- _5 value "inhibition of fibroblast proliferation was mediated exclusively by activation of Epac-1. PGE2 and Epac-1 inhibited cell proliferation through activation of the small GTPase Rap1, since decreasing Rap1 activity by transfection with Rap1GAP or the dominant-negative Rap1N17 prevented, and transfection with the constitutively active Rap1V12 mimicked, the anti-proliferative effects of PGE2" provenance.
- _5 wasQuotedFrom 18421013 provenance.