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- _6 value "During vasculogenesis, angioblasts and early endothelial cells secrete into extracellular matrix Del1, which is a recently discovered ligand for avb3 involved in vascular remodeling (Hidai et al., 1998). In addition, ligation of this integrin complex also promotes a calcium influx required for endothelial motility (Leavesley et al., 1993). The expression of avb3 integrin is induced in microvascular endothelial cells by vascular endothelial growth factor-A (VEGF-A) (Senger et al., 1997), a highly specific activator of in vitro endothelial cell migration and proliferation and in vivo angiogenesis (Thomas, 1996; Ferrara and Davis-Smyth, 1997)." provenance.
- _6 wasQuotedFrom 10022831 provenance.