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- _3 value "Moreover, the critical residue threonine 845 (Thr845) within the activation loop of ASK1 was phosphorylated by ceramide (Figures 5A,S2). The increased phosphorylation of ASK1 Thr845 correlates with ASK1 activation.45,50 Therefore, ceramide caused ASK1 activation by inducing dephosphorylation at Ser83 and phosphorylation at Thr845. " provenance.
- _3 wasQuotedFrom 18270325 provenance.