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- _5 value "All 3 categories of PDE4 isoforms from all four subfamilies can interact with ?-arrestin1/2, implying that a common region in the PDE4 catalytic unit provides a binding site for ?-arrestins [65]. Thus challenge of cells with a ?-agonist has been shown to cause recruitment of a PDE4?arrestin complex to the ?2- AR." provenance.
- _5 wasQuotedFrom 12444918 provenance.