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- _4 value "Whereas the Nrf2 level was very low in the cells cotransfected with WT Keap1, treatment of cells with the proteasome inhibitor MG132 stabilized the Nrf2 protein (Fig. 3A, lanes 1 and 2). The Nrf2 level in cells cotransfected with the R272C mutant was very high and was not induced effectively by MG132 (Fig. 3A, lanes 3 and 4). These results indicate that the R272C mutant impaired Nrf2 degradation." provenance.
- _4 wasQuotedFrom 18316592 provenance.