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- _5 value "In addition to opening the ryanodine receptor, cytoplasmic calcium also stimulates SERCA, which pumps calcium back into the SR. This pump provides another control mechanism to prevent a positive feedback cycle that could irreversibly deplete the SR of calcium. As calcium pumps refill the SR, the rate of Ca2+reuptake slows because of the declining cytoplasmic calcium concentration. ATP also favors SERCA activity; conversely, decreased ATP impairs calcium reuptake. " provenance.
- _5 wasQuotedFrom _4 provenance.