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- _5 value "The interaction of RB and E2F transcription factors represents a functional interaction that has been the predominant focus in the field. RB and the related family members p107 and p130 can each bind E2F to repress genes that are otherwise important for progression from G1 to S phase. The binding of RB, p107, or p130 has two simultaneous consequences: (1) binding prevents E2F from interacting with transcriptional co-activators (e.g., p300); and (2) binding recruits chromatin-modifying enzymes [e.g., histone deacetylases (HDACs)] to silence transcription. E2F itself is a family of transcription factors that include six E2F and three DP proteins, which together form the heterodimeric complex that comprises E2F transcriptional activity (reviewed in Trimarchi and Lees, 2002 and Yee and Wang, 2003). While there is considerable complexity, gene repression in G1 phase utilizes RB and E2Fs 1, 2, 3, and 4, while gene repression in G0 utilizes primarily p130 and E2Fs 4 and 5. binding prevents E2F from interacting with transcriptional co-activators (e.g., p300); and" provenance.
- _5 wasQuotedFrom 15225871 provenance.