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- _3 value "H-rasV12? transduced VSMCs became flat and enlarged in morphology, a characteristic of the senescent phenotype, and were apparently growth arrested by day 3, whereas mock-infected VSMCs exhibited normal morphology and growth (Figures 1A and 2A) ... Whereas only a little SA--gal activity was found in mock-infected injured arteries, transduction of AdenoRas into injured arteries increased SA--gal activity (Figure 3A, left). Immunohistochemical analyses indicated that these SA--gal?positive cells were VSMCs in the outer layer of the intima and the media (Figure 3A, right), which suggests that activation of Ras induced VSMC senescence in vivo as well. " provenance.
- _3 wasQuotedFrom 14557365 provenance.