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- _6 value "Studies using small interfering RNA (siRNA) to inhibit TAK1 expression show that TAK1 is essential for both IL-1- and TNF-?-induced NF-?B activation. Two TAK1-binding proteins, TAB1 and TAB2, have been identified (24, 25). When ectopically co-expressed, TAB1 augments the kinase activity of TAK1, indicating that TAB1 functions as an activator of TAK1." provenance.
- _6 wasQuotedFrom 12893815 provenance.