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- _4 value "Two different constructs of LRP5 were made in which the cytoplasmic tail (LRP5deltaC) or the transmembrane domain and cytoplasmic tail (LRP5deltaTM) were deleted. The two dominant-negative forms decreased ALP activity induced by Wnt3a in both C3H10T1/2 and ST2 cells strongly suggesting that LRP5 modulates the inducing effect of Wnt3a. It was also seen that LRP5deltaC and LRP5deltaTM significantly inhibited the induction of ALP by BMP2 in ST2 AND C3H10T1/2 cells. Moreover, ST2 cells that were stably expressing LRP5deltaC(LRP5deltaC-ST2) were less able to express ALP in response to either Wnt3a or BMP2, compared to ST2 cells stably expressing wild-type LRP5 (LRP5-ST2)." provenance.
- _4 wasQuotedFrom 11719191 provenance.