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- _3 value "indicating that IL-6 effects on muscle metabolism may be mediated through increased lipid availability. Decreases in fatty acid oxidation and increased fatty acid uptake have been proposed as possible mechanisms of increased lipid accumulation, which causes insulin resistance, with obesity (48) and diabetes. Thus elevated fasting plasma IL-6 concentrations would be detrimental to insulin action. Serum IL-6 levels are elevated with obesity (57) and diabetes (28) and are negatively related with insulin-stimulated glucose disposal during a euglycemic-hyperinsulinemic clamp (57)." provenance.
- _3 wasQuotedFrom 16020439 provenance.